Medical Faculty Mannheim
Rolf-Detlef Treede is Professor of Neurophysiology at and managing director of the Center for Biomedicine and Medical Technology Mannheim (CBTM) of the Ruprecht-Karls-University Heidelberg in Mannheim, Germany. After obtaining his “Dr. med.” degree from Hamburg University in 1981, he joined the Department of Physiology at the University Hospital Eppendorf in Hamburg, Germany, until 1988 and again from 1990-1992. From 1988-1990 he was Visiting Scientist with the Department of Neurosurgery at the Johns Hopkins Medical Institutions, Baltimore, USA, and from 1992-2007 Professor of Neurophysiology at the Institute of Physiology and Pathophysiology of the Johannes Gutenberg University in Mainz, Germany.
His wide-ranging interests in the field of pain include the mechanisms and treatment of neuropathic pain, the cortical representation of pain, peripheral nociceptive transduction mechanisms, pain memory, pain assessment by quantitative sensory testing and clinical neurophysiology.
He is Vice-president of the German Association of Scientific Medical Societies, Past President of the German Physiological Society, Past-President of the International Association for the Study of Pain, Past Chair of its Special Interest Group on Neuropathic Pain, and Past President of its German chapter. He sits on numerous national and international committees, and has co-authored about 400 publications in journals and books.
Responsibilities at home organisation
Research, Teaching (Medicine, Biology, translational medical research), Administrative work including activities for national and international societies
Responsibilities within the project
Design, conduct, and reporting of the research project and for managing, monitoring, and ensuring the integrity of the collaborative relationships.
Field of Expertise
- Neurophysiology and Pain Research
Research interests of relevance to the project
- Systems biology
- Mathematical modelling
- Neurobiology of pain and nociception
- Epidemiology of pain and public health
Worked as postdoc fellow/research scientists at:
- Johns Hopkins Medical Institutions
- Klein T, Magerl W, Hanschmann A, Althaus M, Treede RD (2008) Antihyperalgesic and analgesic properties of the N-methyl-D-aspartate (NMDA) receptor antagonist neramexane in a human surrogate model of neurogenic hyperalgesia. Eur J Pain 12: 17-29
- Mueller-Schwefe G, Freytag A, Höer A, Schiffhorst G, Becker A, Casser HR, Glaeske G, Thoma R, Treede RD (2011) Healthcare utilization of back pain patients: results of a claims data analysis. J Med Econ 14: 816-823.
- Treede RD, Rief W, Barke A, Aziz Q, Bennett MI, Benoliel R, Cohen M, Evers S, Finnerup NB, First MB, Giamberardino MA, Kaasa S, Korwisi B, Kosek E, Lavandʼhomme P, Nicholas M, Perrot S, Scholz J, Schug S, Smith BH, Svensson P, Vlaeyen JWS, Wang SJ (2019) Chronic pain as a symptom or a disease: the IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11). Pain 160:19-27.
- Vollert J, Magerl W, Baron R, Binder A, Enax-Krumova EK, Geisslinger G, Gierthmühlen J, Henrich F, Hüllemann P, Klein T, Lötsch J, Maier C, Oertel B, Schuh-Hofer S, Tölle TR, Treede RD (2018) Pathophysiological mechanisms of neuropathic pain: comparison of sensory phenotypes in patients and human surrogate pain models. Pain 159: 1090-1102.
Projects within the RTG Big Data / Supervised students within the RTG Big Data
- Mathematical modelling (PK-PD) for understanding the actions of analgesic medications on functional biomarkers of nociceptive signal processing in the human nervous system (EU project IMI-PainCare)
- Transition from ICD-10 to ICD-11 in Germany: prediction of incidence of new chronic pain codes from existing claims data and extrapolation to effect on healthcare cost