Swagatika Sahoo
Teaching and research
Indian Institute of Technology Madras
Swagatika Sahoo is DST-INSPIRE Faculty at the Department of Chemical Engineering, and Initiative for Biological Systems Engineering (IBSE), Indian Institute of Technology Madras, India. Her career ambition is to develop novel diagnostics and therapeutics for metabolic disorders. She has strong expertise in reconstruction and constraint-based computational modelling of multi-organ metabolic models and a track record of productive work in an interdisciplinary environment. Her current research interests lies in development of hybrid models, i.e., integrating metabolism with upstream singling cascades, or steady-state and dynamic platforms to identify disease drivers. This is being done for metabolic disorders, neurological diseases, and cancer. Once the precise disease pathology is known, the developed models can be used to predict novel diagnostics, e.g., biomarkers, and therapeutics, mainly in terms of diet and medications or their useful combinations. Her research theme is in consonance with P4 medicine (predictive, preventive, participatory, personalized) approach.
Principal Investigator
Further information
Responsibilities within the project
- Project conception
- Formulating workable frameworks
- Setting up project milestones and timelines
- Guiding students
- Preparing manuscripts for publication
Research interests of relevance to the project
Building hybrid models for analysis of large-scale biological data sets
Field of Expertise
- Metabolic modelling
- Systems biology
Selected publications
- A. Sahoo S, Ranjith Kumar R, Nicolay B, Mohite O, Sivaraman K, et al. Metabolite systems profiling identifies exploitable weaknesses in Retinoblastoma. FEBS Lett. 2019; doi:10.1002/1873-3468.13294
- B. Brunk E, Sahoo S, Zielinski DC, Altunkaya A, Dräger A, Mih N, et al. Recon3D enables a three-dimensional view of gene variation in human metabolism. Nat Biotechnol. 2018; 36(3):272-281.
- C. Sahoo S, Haraldsdottir H, Fleming RMT, Thiele I. Modeling the effects of commonly used drugs on human metabolism. FEBS Journal. 2015; 2:297-317.
- D. Sahoo S, Thiele I. Predicting the impact of diet and enzymopathies on human small intestinal epithelial cells. Hum Mol Genet. 2013; 22:2705-22.
- E. Thiele I, Swainston N, Fleming RM, Hoppe A, Sahoo S, et al. A community-driven global reconstruction of human metabolism. Nat Biotechnol. 2013; 31:419-25.
Contact details
Address:
Department of Chemical Engineering
Indian Institute of Technology Madras
Chennai-600036
India
Phone: +91 442 257 4189